You bring what you already are when given the Ring. The mean and basest of the those who come in contact with it look to achieve the meanest and basest of goals; ergo, the petty thief and murderer Sméagol kills and eats his prey and he hides from others. However, the mere thought of the Ring being given to her gives Galadriel a terrible vision of a bright and beautiful queen, like Lucifer the Morningstar. Gandalf won't even touch it, Boromir is driven mad merely being in its proximity and Sauron betrays the Istari and the Valar of the Blessed Realm in order to get it (and he, never even close to it). This then is not a "chemical hook"; it is something else altogether.
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The Ring effectively cuts off human connection.
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Not necessarily. Sméagol was driven away from his clan, he did not leave of his own will. Bilbo existed for decades in the Shire and was beloved by many. Sam did not lose his love for Frodo nor was he driven away even when the Ring reached Mordor. Again, you bring what you are to the Ring, and the Ring merely enhances whatever it is that you are personally, at least your evil aspects are magnified.