Carcharoth was just a wolf who guarded Angband. He bit off the hand that bore the Silmaril and went on a killing spree with newfound power, that's all. He's no werewolf or vampire, just and ordinary wolf. Drauglin is the werewolf and Thuringwethil is the vampire. Drauglin's nothing special either, but Thuringwethil seems to have been at least a little "uber" in terms of power.
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"What mortal feels not awe/Nor trembles at our name,
Hearing our fate-appointed power sublime/Fixed by the eternal law.
For old our office, and our fame,"
-Aeschylus, Song of the Furies
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