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First thought was literal poisons - eg Belladonna. But she is not one of four, and I don't remember hobbit family trees enough to thibk of one who is.
What things are in a set of four? Compass points? Farthings? Seasons? It's not a common Tolkien number.
It would have been interesting if bringing to death's door meant to physocally bring Huan to Thangorodrim or the Black Gate, but based on Pervinca's post above this sounds less likely.
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You passed from under darkened dome, you enter now the secret land. - Take me to Finrod's fabled home!... ~ Finrod: The Rock Opera
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