I think what also is important here is the fact that he simply did not need a plague during the WotR.
This is an easy explanation for many things that Sauron could have well used and did not - he was so confident and arrogant that he needed not bother come up with complicated plans, he knew that eventually he would defeat the West. Of course that turned out to be a mistake in the end...
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“The invisible and the non-existent look very much alike.”
Delos B. McKown
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