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At least American Indians, who had been harvesting tobacco for a long time before the Europeans came, suffered less from the side-effects of tobacco than the Europeans. I don't know about Hobbits though- if I remember correctly, smoking pipeweed was a relatively new practice among them, so the immunity should have developed in a very short time.
But hobbits are quite tough. If even the Ring didn't affect them as strongly as it would have some other race, maybe smoking pipeweed caused no problem either.
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He bit me, and I was not gentle.
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